Editorial: Tissue Repair and Regenerative Mechanisms by Stem/Progenitor Cells and Their Secretome

Frontiers in Medicine

article

Roberto Gramignoli¹  Fabio Sallustio²  Darius Widera³  Nathanael Raschzok⁴ 

[1] Department of Laboratory Medicine, Karolinska Institutet;Department of Basic Medical Sciences, University of Bari Aldo Moro;Stem Cell Biology and Regenerative Medicine Group, Reading School of Pharmacy, University of Reading, United Kingdom;Department of Surgery, Charité - Universitätsmedizin Berlin

关键词: tissue repair and regeneration;    regenerative mechanism;    stem cells;    progenitor cells;    secretome;   

DOI  :  10.3389/fmed.2019.00011

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Regenerative medicine is a branch of translational research which is energizing and empowering clinical practice. A multitude of novel approaches proposed during the recent years is slowly but dramatically transforming the health care system, harnessing the power of repairing, replacing, restoring, and regenerating human organs and tissues affected by various degenerative disorders and diseases. During the twentieth century, hundreds of thousands of patients with end-stage diseases have been rescued by solid organ transplants as ultimate treatment option. In the past 3 decades, cell-based therapies have been gaining importance since they can contribute to regeneration of failing organs or damaged tissues by direct replacement of the lost cells or by facilitating the body’s natural regenerative processes by removing roadblocks. A growing armamentarium of therapeutic options, spanning from bioartificial organs and tissues, stem and progenitor cells, biomaterials, cell secretome, and extracellular vesicles have become available as medical treatments substituting the standard pharmaceutics.

【 授权许可】

CC BY