State-Related Alterations of Spontaneous Neural Activity in Current and Remitted Depression Revealed by Resting-State fMRI

Frontiers in Psychology

article

Chang Cheng¹  Daifeng Dong¹  Yali Jiang¹  Qingsen Ming³  Xue Zhong¹  Xiaoqiang Sun¹  Ge Xiong¹  Yidian Gao¹  Shuqiao Yao¹ 

[1] Medical Psychological Center, The Second Xiangya Hospital, Central South University;Preschool Education Department, Changsha Normal University;Department of Psychiatry, The First Affiliated Hospital of Soochow University, Soochow University

关键词: major depressive disorder;    remission;    trait-related;    state-related;    resting-state fMRI;    amplitude of low-frequency fluctuation;   

DOI  :  10.3389/fpsyg.2019.00245

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Purpose: Although efforts have been made to identify neurobiological characteristic of major depressive disorder (MDD) in recent years, trait- and state-related biological characteristics of MDD still remains unclear. Using functional magnetic resonance imaging (fMRI), the aim of this study was to explore whether altered spontaneous neural activities in MDD are trait- or state- related. Materials and Methods: Resting-state fMRI data were analyzed for 72 current MDD (cMDD) patients (first-episode, medication-naïve), 49 remitted MDD (rMDD) patients, and 78 age- and sex- matched healthy control (HC) subjects. The values of amplitude of low-frequency fluctuation (ALFF) were compared between groups. Results: Compared with the cMDD group, the rMDD group had increased ALFF values in the left middle occipital gyrus, left middle temporal gyrus and right cerebellum anterior lobe. Besides, compared with the HC group, the cMDD group had decreased ALFF values in the left middle occipital gyrus. Further analysis explored that the mean ALFF values in the left middle occipital gyrus, left middle temporal gyrus and right cerebellum anterior lobe were correlated positively with BDI scores in rMDD patients. Conclusion: Abnormal activity in the left middle occipital gyrus, left middle temporal gyrus and right cerebellum anterior lobe may be state-specific in current (first-episode, medication-naïve) and remitted (medication-naïve) depression patients. Furthermore, the state-related compensatory effect was found in these brain areas.

【 授权许可】

CC BY