Frontiers in Public Health | |
Quantitative SARS-CoV-2 Antibody Screening of Healthcare Workers in the Southern Part of Kyoto City During the COVID-19 Pre-pandemic Period | |
article | |
Kohei Fujita1  Shinpei Kada2  Osamu Kanai1  Hiroaki Hata2  Takao Odagaki2  Noriko Satoh-Asahara6  Tetsuya Tagami6  Akihiro Yasoda6  | |
[1] Division of Respiratory Medicine, Center for Respiratory Diseases, National Hospital Organization Kyoto Medical Center;Department of Infectious Diseases, National Hospital Organization Kyoto Medical Center;Department of Otolaryngology, National Hospital Organization Kyoto Medical Center;Department of Surgery, National Hospital Organization Kyoto Medical Center;Department of General Medicine, National Hospital Organization Kyoto Medical Center;Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center;Division of Endocrinology, and Hypertension Research, Clinical Research Institute, National Hospital Organization Kyoto Medical Center | |
关键词: COVID-19; seroprevalence; SARS-CoV-2; ELISA; antibody; | |
DOI : 10.3389/fpubh.2020.595348 | |
学科分类:社会科学、人文和艺术(综合) | |
来源: Frontiers | |
【 摘 要 】
Background: The coronavirus disease-2019 (COVID-19) pandemic is associated with a heavy burden on the mental and physical health of patients, regional healthcare resources, and global economic activity. While understanding of the incidence and case-fatality rates has increased, there are limited data concerning seroprevalence of antibodies against the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) in healthcare workers during the pre-pandemic period. This study aimed to quantitatively evaluate seroprevalence of SARS-CoV-2 antibodies in healthcare workers in the southern part of Kyoto city, Japan. Methods: We prospectively recruited healthcare workers from a single hospital between April 10 and April 20, 2020. We collected serum samples from these participants and quantitatively evaluated SARS-CoV-2 IgG antibody levels using enzyme-linked immunosorbent assays. Results: Five (5.4%), 15 (16.3%), and 72 (78.3%) participants showed positive, borderline, and negative serum SARS-CoV-2 IgG antibody status, respectively. We found the mean titer associated with each antibody status (overall, positive, borderline, and negative) was clearly differentiated. Participants working at the otolaryngology department and/or with a history of seasonal common cold symptoms had a significantly higher SARS-CoV-2 IgG antibody titer ( p = 0.046, p = 0.046, respectively). Conclusions: Five (5.4%) and 15 (16.3%) participants tested positive and borderline, respectively, for SARS-CoV-2 IgG antibody during the COVID-19 pre-pandemic period. These rates were higher than expected, based on government situation reports. These findings suggest that COVID-19 had already spread within the southern part of Kyoto city at the early stage of the pandemic.
【 授权许可】
CC BY
【 预 览 】
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