Effectiveness of antibacterial agents against cell-invading bacteria such as Streptococcus pyogenes and Haemophilus influenzae

BMC Microbiology

article

Iuchi, Hiroyuki¹  Ohori, Junichiro¹  Kiyama, Satoshi¹  Imuta, Naoko²  Nishi, Junichiro²  Kurono, Yuichi¹  Yamashita, Masaru¹ 

[1] Department of Otolaryngology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University;Department of Microbiology, Graduate School of Medical and Dental Sciences, Kagoshima University

关键词: Antibacterial agents;    Haemophilus influenzae;    Streptococcus pyogenes;    Susceptibility;    Garenoxacin;    emm typing;   

DOI  :  10.1186/s12866-021-02217-y

学科分类：放射科、核医学、医学影像

来源: BioMed Central

【 摘 要 】

Recurrent tonsillitis is one of the most common otolaryngological disorders caused by cell-invading bacteria, such as Streptococcus pyogenes (S. pyogenes) and Haemophilus influenzae. The aim of this study was to investigate the effect of antibacterial agents against cell-invading bacteria. The intracellular invasion of Detroit 562 cells by five strains of nontypeable Haemophilus influenzae (NTHi) and four strains of S. pyogenes was investigated. The antibacterial agents used were garenoxacin (GRNX), clarithromycin (CAM), amoxicillin (AMPC), cefditoren pivoxil (CDTR-PI), and levofloxacin (LVFX). Both NTHi and S. pyogenes fully invaded Detroit 562 cells in 6 h and were less sensitive to CAM. GRNX, CAM, and LVFX were effective against bacteria invading the cells, but AMPC and CDTR-PI were not effective. GRNX was the most effective. GRNX was the most effective agent against bacteria invading cells.

【 授权许可】

CC BY|CC0