Effectiveness of antibacterial agents against cell-invading bacteria such as Streptococcus pyogenes and Haemophilus influenzae

BMC Microbiology

Naoko Imuta¹  Junichiro Nishi¹  Masaru Yamashita²  Junichiro Ohori²  Yuichi Kurono²  Satoshi Kiyama²  Hiroyuki Iuchi² 

[1] Department of Microbiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan;Department of Otolaryngology, Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan;

关键词: Antibacterial agents;    Haemophilus influenzae;    Streptococcus pyogenes;    Susceptibility;    Garenoxacin;    emm;   

DOI  :  10.1186/s12866-021-02217-y

来源: Springer

【 摘 要 】

BackgroundRecurrent tonsillitis is one of the most common otolaryngological disorders caused by cell-invading bacteria, such as Streptococcus pyogenes (S. pyogenes) and Haemophilus influenzae. The aim of this study was to investigate the effect of antibacterial agents against cell-invading bacteria.MethodsThe intracellular invasion of Detroit 562 cells by five strains of nontypeable Haemophilus influenzae (NTHi) and four strains of S. pyogenes was investigated. The antibacterial agents used were garenoxacin (GRNX), clarithromycin (CAM), amoxicillin (AMPC), cefditoren pivoxil (CDTR-PI), and levofloxacin (LVFX).ResultsBoth NTHi and S. pyogenes fully invaded Detroit 562 cells in 6 h and were less sensitive to CAM. GRNX, CAM, and LVFX were effective against bacteria invading the cells, but AMPC and CDTR-PI were not effective. GRNX was the most effective.ConclusionGRNX was the most effective agent against bacteria invading cells.

【 授权许可】

CC BY