Gut microbiota: effect of pubertal status

BMC Microbiology

article

Yuan, Xin¹  Chen, Ruimin¹  Zhang, Ying¹  Lin, Xiangquan¹  Yang, Xiaohong¹ 

[1] Department of Endocrinology, Fuzhou Children’s Hospital of Fujian Medical University

关键词: Puberty;    Children;    Adolescent;    16 s rRNA;    Gut microbiota;   

DOI  :  10.1186/s12866-020-02021-0

学科分类：放射科、核医学、医学影像

来源: BioMed Central

【 摘 要 】

The make-up of gut microbiota at different puberty stages has not been reported. This cross-sectional study analyzed the bio-diversity of gut microbiota at different puberty stages. The subjects (aged 5–15 years) were divided into non-pubertal (n = 42, male%: 66.7%) or pubertal groups (n = 47, male%:44.68); in both groups, Firmicutes, Bacteroidetes and Proteobacteria were the dominant phylum. There was no difference of alpha- and beta-diversity among disparate puberty stages. Non-pubertal subjects had members of the order Clostridiales, family Clostridiaceae, genus Coprobacillus which were significantly more prevalent than puberty subjects. Also, the pubertal subjects had members of class Betaproteobacteria, order Burkholderiales which were significantly more prevalent than the non-pubertal subjects. Their relative abundance was independent of BMI-Z. In the pubertal subjects, the abundance of genus Adlercreutzia, Ruminococcus, Dorea, Clostridium and Parabacteroides was associated with the level of testosterone. This is the first report of the diversity of gut microbiota at different puberty stages. The various species of gut microbiota changed gradually associated with puberty stages. Differences in gut microflora at different pubertal status may be related to androgen levels.

【 授权许可】

CC BY|CC0