Gut microbiota: effect of pubertal status

BMC Microbiology

Xiaohong Yang¹  Ying Zhang¹  Xiangquan Lin¹  Xin Yuan¹  Ruimin Chen¹ 

[1] Department of Endocrinology, Genetics and Metabolism, Fuzhou Children’s Hospital of Fujian Medical University, NO.145, 817 Middle Road, 350005, Fuzhou, China;

关键词: Puberty;    Children;    Adolescent;    16 s rRNA;    Gut microbiota;   

DOI  :  10.1186/s12866-020-02021-0

来源: Springer

【 摘 要 】

BackgroundThe make-up of gut microbiota at different puberty stages has not been reported. This cross-sectional study analyzed the bio-diversity of gut microbiota at different puberty stages.ResultThe subjects (aged 5–15 years) were divided into non-pubertal (n = 42, male%: 66.7%) or pubertal groups (n = 47, male%:44.68); in both groups, Firmicutes, Bacteroidetes and Proteobacteria were the dominant phylum. There was no difference of alpha- and beta-diversity among disparate puberty stages. Non-pubertal subjects had members of the order Clostridiales, family Clostridiaceae, genus Coprobacillus which were significantly more prevalent than puberty subjects. Also, the pubertal subjects had members of class Betaproteobacteria, order Burkholderiales which were significantly more prevalent than the non-pubertal subjects. Their relative abundance was independent of BMI-Z. In the pubertal subjects, the abundance of genus Adlercreutzia, Ruminococcus, Dorea, Clostridium and Parabacteroides was associated with the level of testosterone.ConclusionsThis is the first report of the diversity of gut microbiota at different puberty stages. The various species of gut microbiota changed gradually associated with puberty stages. Differences in gut microflora at different pubertal status may be related to androgen levels.

【 授权许可】

CC BY