Successful outcome after a single endoscopic fecal microbiota transplantation in a Shiba dog with non-responsive enteropathy during the treatment with chlorambucil

The Journal of Veterinary Medical Science

article

Koji SUGITA¹  Keitaro OHMORI¹  Ayaka SHIMA³  Kaho TAKAHASHI¹  Yasuyoshi MATSUDA¹  Masaki MIYAJIMA¹  Marin HIROKAWA¹  Hirotaka KONDO⁴  Junpei KIMURA⁵  Genki ISHIHARA³ 

[1] Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology;Sugita Animal Hospital;Anicom Specialty Medical Institute Inc.;Laboratory of Veterinary Pathology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University;College of Veterinary Medicine and Research Institute for Veterinary Medicine, Seoul National University

关键词: dysbiosis;    fecal microbiota transplantation;    hypoalbuminemia;    non-responsive enteropathy;    Shiba dog;   

DOI  :  10.1292/jvms.21-0063

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

A 7-year 6-month-old, castrated male Shiba dog presented with a 1-month history of lethargy, anorexia, vomiting, and frequent watery diarrhea. Weight loss, hypoalbuminemia, anemia, and leukocytosis were detected at the first visit. The dog was diagnosed with non-responsive enteropathy (NRE) based on clinical and histopathological examinations. Since the dog did not respond to the immunosuppressive drugs, fecal microbiota transplantation (FMT) was performed during the treatment with chlorambucil. A single endoscopic FMT into the cecum and colon drastically recovered clinical signs and clinicopathological abnormalities and corrected dysbiosis in the dog. No recurrence or adverse events were observed. The present case report suggests that FMT, possibly together with chlorambucil, might be a treatment option for NRE in Shiba dogs that have poorer prognosis compared with other dog breeds.

【 授权许可】

Unknown