Minocycline prevents primary duck neurons from duck Tembusu virus-induced death

The Journal of Veterinary Medical Science

article

Sittinee KULPRASERTSRI¹  Keisuke AOSHIMA¹  Atsushi KOBAYASHI¹  Takashi KIMURA¹ 

[1] Laboratory of Comparative Pathology, Faculty of Veterinary Medicine, Hokkaido University

关键词: bird;    duck Tembusu virus;    minocycline;    neuroprotective effect;    primary duck neuron;   

DOI  :  10.1292/jvms.20-0735

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

Duck Tembusu virus (DTMUV), a neurotropic flavivirus, is a causative agent of severe neurological diseases in different birds. No approved vaccines or antiviral therapeutic treatments are available to date. The poultry industry experiences significant economic losses due to DTMUV infections. Minocycline is a second-generation semi-synthetic tetracycline analogue that is commonly used as an antimicrobial treatment. Experimental studies have indicated the successful protective effects of minocycline against neuronal cell death from neurodegenerative diseases and viral encephalitis. The aim of this study was to investigate the effects of minocycline on DTMUV infection in neurons. Primary duck neurons were treated with minocycline, which exhibited neuroprotective effects via anti-apoptotic function rather than through viral replication inhibition. Minocycline might serve as a potential effective drug in DTMUV infection.

【 授权许可】

Unknown