Expression of P-glycoprotein and breast cancer resistance protein in three cases of canine lymphoma showing drug resistance

The Journal of Veterinary Medical Science

article

Sachiko HYOKAI¹  Hiroyo TANAKA¹  Noriyuki AIHARA¹  Junichi KAMIIE¹ 

[1] Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University;Pfizer R&D Japan G.K.

关键词: breast cancer resistance protein;    dog;    immunohistochemistry;    lymphoma;    P-glycoprotein;   

DOI  :  10.1292/jvms.20-0718

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

In canine lymphoma, drug resistance is the major factor hindering treatment. In this study, we performed immunohistochemical examination of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), which are considered as transporters related to multidrug resistance in three recurrent canine lymphomas. All cases were negative for both transporters before anticancer drug administration, but became positive after this administration. The expression was confirmed in capillary endothelial cells, such as in brain capillaries acting as the blood-brain barrier (BBB). It is suggested that both transporters expressed on capillary endothelial cells in lymphoma tissue may inhibit the spread of anticancer drugs into tumor tissues from blood, the same as the BBB. Therefore, capillary endothelial cells could act as a blood-tumor barrier, which might be involved in drug resistance in canine lymphoma.

【 授权许可】

Unknown