A Straightforward Synthesis of Enantiopure (1 S ,2 R )-Ephenamine

Journal of the Brazilian Chemical Society

article

Velho, Arthur C. C.¹  Martins, José E. D.¹ 

[1] Instituto de Química, Universidade Federal Rural do Rio de Janeiro

关键词: chiral auxiliary;    chiral amino alcohols;    (1S;    2R)-ephenamine;   

DOI  :  10.21577/0103-5053.20200121

学科分类：内科医学

来源: SciELO

【 摘 要 】

An enantioselective six-step synthesis of (1 S ,2 R )-ephenamine starting from readily available chiral amino acid is disclosed presenting 26% overall yield and high optical purity. The use of chiral phenylglycine as starting material was also studied and did not present satisfactory results due to a very sensitive a-carbonyl/benzylic stereogenic center that, in our hands, led to racemization.

【 授权许可】

CC BY