Single nucleotide polymorphisms in microRNAs action as biomarkers for breast cancer

Turkish journal of biology

article

THANH THI NGOC NGUYEN¹  MINH THI HONG TRAN¹  VY THI LAN NGUYEN¹  UYEN DOAN PHUONG NGUYEN¹  GIANG DIEN THANH NGUYEN¹  LUAN HUU HUYNH¹  HUE THI NGUYEN¹ 

[1] Department of Physiology and Animal Biotechnology, Faculty of Biology and Biotechnology, University of Science;Vietnam National University

关键词: Breast cancer;    microRNA;    miRNA;    single nucleotide polymorphism;    SNP;   

DOI  :  10.3906/biy-2004-78

学科分类：生物科学（综合）

来源: Scientific and Technical Research Council of Turkey - TUBITAK

【 摘 要 】

MicroRNAs (miRNAs) have been recently described as small noncoding RNAs that are involved in numerous crucial physiological processes, such as cell cycles, differentiation, development, and metabolism. Thus, dysregulation of these molecules could lead to several severe disorders, including breast cancer (BC). Ongoing investigations in malignant growth diagnostics have distinguished miRNAs as promising disease biomarkers. As with any other mRNAs, single nucleotide polymorphisms (SNPs) in DNA sequence encoding for miRNA (miR-SNPs) indeed lead to potential changes in the function of miRNA. In this study, miR-SNPs located in different miRNA sequence regions, which have been associated with BC in different ways, and the potential mechanisms of how these miR-SNPs develop the risk of the disease were discussed.

【 授权许可】

Unknown