An immunotherapeutic approach to decipher the role of long non-coding RNAs in cancer progression, resistance and epigenetic regulation of immune cells

Journal of Experimental & Clinical Cancer Research

Hemavathi Dhandapani¹  Jialei Song²  Wuling Liu³  Yanmei Li³  Anling Hu³  Yaacov Ben-David³  Chunlin Wang³  Krishnapriya M. Varier⁴  Babu Gajendran⁴  Xiangchun Shen⁴ 

[1] Department of Molecular Oncology, Cancer Institute (WIA), 600020, Chennai, India;Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, 400076, Mumbai, India;Guizhou University of Traditional Chinese Medicine, 550025, Guiyang, Guizhou Province, People’s Republic of China;State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, 550014, Guiyang, Guizhou Province, People’s Republic of China;The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academic of Sciences, 550014, Guiyang, Guizhou Province, People’s Republic of China;State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, 550014, Guiyang, Guizhou Province, People’s Republic of China;The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academic of Sciences, 550014, Guiyang, Guizhou Province, People’s Republic of China;School of Pharmaceutical Sciences, Guizhou Medical University, 550025, Guiyang, Guizhou Province, People’s Republic of China;

关键词: LncRNAs;    Adaptive and innate immune cells;    Immunotherapy;    Epigenetics;    Autophagy;   

DOI  :  10.1186/s13046-021-01997-5

来源: Springer

【 摘 要 】

Immunotherapeutic treatments are gaining attention due to their effective anti-tumor response. Particularly, the revolution of immune checkpoint inhibitors (ICIs) produces promising outcomes for various cancer types. However, the usage of immunotherapy is limited due to its low response rate, suggesting that tumor cells escape the immune surveillance. Rapid advances in transcriptomic profiling have led to recognize immune-related long non-coding RNAs (LncRNAs), as regulators of immune cell-specific gene expression that mediates immune stimulatory as well as suppression of immune response, indicating LncRNAs as targets to improve the efficacy of immunotherapy against tumours. Moreover, the immune-related LncRNAs acting as epigenetic modifiers are also under deep investigation. Thus, herein, is a summarised knowledge of LncRNAs and their regulation in the adaptive and innate immune system, considering their importance in autophagy and predicting putative immunotherapeutic responses.

【 授权许可】

CC BY