The role of lncRNAs and circRNAs in the PD-1/PD-L1 pathway in cancer immunotherapy

Molecular Cancer

Shuya Pan¹  Zhi-wei Wang¹  Xueqiong Zhu¹  Wenxiao Jiang¹  Xin Chen¹ 

[1] Departmant of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University;

关键词: LncRNAs;    Cancer;    CircRNAs;    PD-1;    PD-L1;    Immunotherapy;   

DOI  :  10.1186/s12943-021-01406-7

来源: DOAJ

【 摘 要 】

Abstract Cancer immunotherapy has recently shown promising antitumor effects in various types of tumors. Among all immune checkpoints, the PD-1/PD-L1 pathway plays an important role in the immune evasion of tumor cells, making it a potent target in antitumor immunity. Accordingly, antibodies targeting the PD-1/PD-L1 pathway have been developed to attack tumor cells; however, resistance to immune therapy remains to be solved. Hence, identification of the underlying modulators of the PD-1/PD-L1 pathway is of significant importance to understand the mechanisms of antitumor immunotherapy. Long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) have been identified to regulate the PD-1/PD-L1 pathway, leading to participation in the immune response and immunotherapy. Therefore, this review focuses on the functions of lncRNAs and circRNAs in regulation of the PD-1/PD-L1 axis in tumorigenesis and tumor progression. We hope this review will stimulate research to supply more precise and effective cancer immune checkpoint therapies for a large number of tumors.

【 授权许可】

Unknown