Biomimetic recombinant of red blood cell membranes for improved photothermal therapy

Journal of Nanobiotechnology

Xing Jiang¹  Tianqing Liu²  Ying Yang³  Shuai Yin³  Pengkai Wu⁴  Kaikai Wang⁵ 

[1] College of Nursing, Nanjing University of Chinese Medicine, 210029, Nanjing, China;NICM Health Research Institute, Western Sydney University, 2145, Westmead, Australia;School of Pharmacy, Nantong University, 226001, Nantong, China;School of Pharmacy, Nantong University, 226001, Nantong, China;Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, 210093, Nanjing, China;School of Pharmacy, Nantong University, 226001, Nantong, China;Nantong Municipal Hospital of Traditional Chinese Medicine, 226001, Nantong, China;

关键词: Drug Delivery;    Red blood cell membrane;    Disassembly-Reassembly;    IR780;    Photothermal Therapy;   

DOI  :  10.1186/s12951-021-00949-7

来源: Springer

【 摘 要 】

BackgroundRBC membrane derived nanoparticles (NPs) represent an emerging platform with prolonged circulation capacity for the delivery of active substances. For functionalize derived RBCs NPs, various strategies, such as biomimetic rebuilding of RBCs, chemical modification or inserting ligands, have been carried out to improve their performance. However, one potential adverse effect for these methods is the structural failure of membrane proteins, consequently affecting its original immune escape function.ResultsIn this study, we reported a green technology of “disassembly-reassembly” to prepare biomimetic reconstituted RBCs membrane (rRBCs) by separating the endogenous proteins and lipids from nature RBC membrane. IR780 iodide was used as a pattern drug to verify the property and feasibility of rRBCs by constructing IR780@rRBC NPs with IR780@RBC NPs and free IR780 as controls. The results demonstrated the superiority of IR780@rRBC NPs in toxicity, stability, pharmacokinetics and pharmacodynamics compared with IR780@rRBC and free IR780.ConclusionsThe reported “disassembly-reassembly” strategy shows great potential to produce controllable and versatile rRBC membrane-inspired delivery platform, which may be used to overcome the deficiency of functionalization in cell membrane coated nanoparticles .Graphic abstract

【 授权许可】

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