IR780 Based Sonotherapeutic Nanoparticles to Combat Multidrug-Resistant Bacterial Infections

Frontiers in Chemistry

Chemistry

Long Wang¹  Haiqin Liao²  Sijie Chen²  Chengcheng Niu²  Kui Tang²  Biying Huang²  Yan Xu² 

[1] Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China;Hunan Engineering Research Center of Biomedical Metal and Ceramic Implants, Xiangya Hospital, Central South University, Changsha, China;National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China;Hunan Key Laboratary of Aging Biology, Xiangya Hospital, Central South University, Changsha, China;Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China;Research Center of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, China;

关键词: IR780;    sonodynamic therapy;    multidrug-resistant bacterial infections;    antibacterial therapy;    reactive oxygen species;   

DOI  :  10.3389/fchem.2022.840598

 received in 2021-12-21, accepted in 2022-01-04,  发布年份 2022

来源: Frontiers

【 摘 要 】

Multidrug-resistant (MDR) bacterial strains have emerged and weakened the therapeutic effects of antibacterial drugs. Sonodynamic therapy (SDT) takes advantage of noninvasiveness and deep tissue-penetrating features and has been rejuvenated to combat MDR bacteria and their biofilm-associated infections. To improve the efficacy of antibacterial SDT, we first developed IR780-based PLGA nanoparticles as sonosensitizers for high-frequency ultrasound (US)-monitored antibacterial SDT of MRSA myositis by therapeutic low-frequency US. In this study, the developed shell-core-structured IR780@PLGA nanoparticles were designed with a polymer shell PLGA with the sonosensitizer IR780 loaded on. High-frequency diagnostic US was introduced to monitor the sonotherapeutic progression of bacterial myositis by therapeutic low-frequency US. Importantly, the in vitro and in vivo results confirmed that IR780@PLGA nanoparticles combined with US irradiation possess high efficiency for antibacterial therapy. This approach provides a simple and efficient strategy to monitor and combat MDR bacterial infection.

【 授权许可】

Unknown   
Copyright © 2022 Huang, Wang, Tang, Chen, Xu, Liao and Niu.