Molecular mechanism study of HGF/c-MET pathway activation and immune regulation for a tumor diagnosis model

Cancer Cell International

Lifeng Li¹  Le Wang²  Wenhua Xue³  Yuanyuan Zheng⁴  Zhibo Shen⁴  Wenbin Wang⁵  Qishun Geng⁵  Jie Zhao⁵  Zhirui Fan⁶  Ying Yue⁷  Yunkai Zhai⁸ 

[1] Cancer Center, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan, People’s Republic of China;Internet Medical and System Applications of National Engineering Laboratory, Zhengzhou, China;Department of Otorhinolaryngology, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan, People’s Republic of China;Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan, People’s Republic of China;Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan, People’s Republic of China;Cancer Center, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan, People’s Republic of China;Internet Medical and System Applications of National Engineering Laboratory, Zhengzhou, China;Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan, People’s Republic of China;Internet Medical and System Applications of National Engineering Laboratory, Zhengzhou, China;Department of Traditional Chinese Medicine, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan, People’s Republic of China;Department of clinical laboratory, The No.7.People’s Hospital of Zhengzhou, 450016, Zhengzhou, Henan, China;Internet Medical and System Applications of National Engineering Laboratory, Zhengzhou, China;

关键词: HGF;    c-MET;    RNAseq;    Immune cells;    Pathway score;    Immune infiltration;    Diagnostic predictor;    Prognosis;   

DOI  :  10.1186/s12935-021-02051-2

来源: Springer

【 摘 要 】

BackgroundHepatocyte growth factor (HGF) binds to the c-mesenchymal-epithelial transition (C-MET) receptor and activates downstream signaling pathways, playing an essential role in the development of various cancers. Given the role of this signaling pathway, the primary therapeutic direction focuses on identifying and designing HGF inhibitors, antagonists and other molecules to block the binding of HGF to C-MET, thereby limiting the abnormal state of other downstream genes.MethodsThis study focuses on the analysis of immune-related genes and corresponding immune functions that are significantly associated with the HGF/c-MET pathway using transcriptome data from 11 solid tumors.ResultsWe systematically analyzed 11 different cancers, including expression correlation, immune infiltration, tumor diagnosis and survival prognosis from HGF/c-MET pathway and immune regulation, two biological mechanisms having received extensive attention in cancer analysis.ConclusionWe found that the HGF/c-MET pathway affected the tumor microenvironment mainly by interfering with expression levels of other genes. Immune infiltration is another critical factor involved in changes to the tumor microenvironment. The downstream immune-related genes activated by the HGF/c-MET pathway regulate immune-related pathways, which in turn affect the degree of infiltration of immune cells. Immune infiltration is significantly associated with cancer development and prognosis.

【 授权许可】

CC BY