A comparison of cognitive performances between neuromyelitis optica spectrum disorder and multiple sclerosis patients in Indian context

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Shambaditya Das¹  Goutam Gangopadhyay¹  Souvik Dubey¹  Biman Kanti Ray¹  Atanu Biswas¹  Swati Kumar¹  Alak Pandit¹ 

[1] Department of Neurology, Bangur Institute Of Neurosciences, IPGMER and SSKM Hospital, 52 1/A Sambhu Nath Pandit Road, Bhowanipore, 700020, Kolkata, West Bengal, India;

关键词: Neuromyelitis optica spectrum disorders;    Multiple sclerosis;    Cognitive impairment;   

DOI  :  10.1186/s41983-021-00351-y

来源: Springer

【 摘 要 】

BackgroundTo compare the frequency and pattern of cognitive impairment in neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) patients.ResultsTwenty NMOSD and forty MS patients were included. Clinical and detailed neuropsychological assessment was done using frontal assessment battery and Kolkata cognitive battery supplemented with additional standard tests for different domains of cognitive functions. Domain wise tests were performed and compared. 15/20 (75%) NMOSD and 32/40 (80%) MS patients had cognitive impairment (p = 0.65). Executive function, verbal fluency, information processing speed, visuo-constructional ability, attention, complex calculation, and memory were more commonly involved in NMOSD in decreasing order. Compared to MS, the pattern was similar except that verbal fluency was more impaired in NMOSD. Expanded Disability Status scale (EDSS) correlated with cognitive involvement in NMOSD (p = 0.02) as against MS.ConclusionsExecutive function, verbal fluencies, and information processing speed were more affected compared to visual and verbal memory in NMOSD patients. The pattern of cognitive performance was similar in the MS group, even though clinical and radiological characteristics and pathophysiology is different, suggesting similar brain involvement.

【 授权许可】

CC BY