Lower urinary tract signs and symptoms in patients with COVID-19

BMC Infectious Diseases

Hadi Mostafae¹  Dick Janssen²  John Heesakkers²  Morteza Ghojazadeh³  Hanieh Salehi-Pourmehr³  Sakineh Hajebrahimi³  Christian Bach⁴  Thomas Alexander Vögeli⁴  Mohammad Sajjad Rahnama’i⁵  Aida Javan Balegh Marand⁶ 

[1] Medical University of Vienna, Tabriz, Austria;Radboud University, Nijmegen, The Netherlands;Research Center for Evidence-Based Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;Uniklinik RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany;Uniklinik RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany;Radboud University, Nijmegen, The Netherlands;Uniklinik RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany;Radboud University, Nijmegen, The Netherlands;Society of Urological Research and Education (SURE), Heerlen, The Netherlands;

关键词: Lower urinary tract symptoms (LUTS);    COVID-19;    SARS-CoV-2;    Hematuria;    Urine, leukocyturia;   

DOI  :  10.1186/s12879-021-06394-z

来源: Springer

【 摘 要 】

BackgroundThe type of pneumonia that is caused by the new coronavirus (SARS-CoV-2) has spread across the world in a pandemic. It is not clear if COVID-19 patients have any lower urinary tract signs or symptoms.MethodsThe effect of COVID-19 on lower urinary tract function was studied in a prospective multi-centre, observational study including 238 patients who were admitted with symptoms caused by COVID-19 to the university hospital of Aachen in Germany and Tabriz in Iran.ResultsNone of the patients reported to have any lower urinary tract symptoms. SARS-CoV-2 was found in the urine of 19% of the tested patients.The mortality rate in COVID-19 infected patients with microscopic haematuria together with white blood cells in their urine, was significantly increased from 48 to 61% in the Tabriz cohort (p-value = 0.03) and from 30 to 35% in the Aachen cohort (p-value =0.045). Furthermore, in the group of patients with SARS-CoV-2 urine PCR, the mortality rate rose from 30 to 58%. (p-value =0.039).ConclusionPatients admitted with COVID-19 did not report to have any lower urinary tract symptoms, even those patient who had a positive Urine SARS-CoV-2 PCR.In addition, hematuria, WBC in urine as well as SARS- CoV-2 presence in urine, were found to be strong negative prognostic factors in admitted COVID-19 patients.

【 授权许可】

CC BY