YTHDF2 facilitates UBXN1 mRNA decay by recognizing METTL3-mediated m6A modification to activate NF-κB and promote the malignant progression of glioma

Journal of Hematology & Oncology

Ke-Nan Zhang¹  Yuan-Hao Chang¹  Rui-Chao Chai¹  Bo Pang¹  Yu-Zhou Chang²  Yong-Zhi Wang³  Tao Jiang³  Xin Chang⁴  Song Yuan An⁵ 

[1] Department of Molecular Neuropathology, Department of Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, No. 119 Nan Si Huan Xi Road, Fengtai District, 100050, Beijing, China;Chinese Glioma Genome Atlas Network (CGGA), Beijing, China;Department of Molecular Neuropathology, Department of Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, No. 119 Nan Si Huan Xi Road, Fengtai District, 100050, Beijing, China;Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 Nan Si Huan Xi Road, Fengtai District, 100050, Beijing, China;Department of Molecular Neuropathology, Department of Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, No. 119 Nan Si Huan Xi Road, Fengtai District, 100050, Beijing, China;Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 Nan Si Huan Xi Road, Fengtai District, 100050, Beijing, China;Chinese Glioma Genome Atlas Network (CGGA), Beijing, China;Department of Molecular Neuropathology, Department of Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, No. 119 Nan Si Huan Xi Road, Fengtai District, 100050, Beijing, China;Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China;Chinese Glioma Genome Atlas Network (CGGA), Beijing, China;Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 Nan Si Huan Xi Road, Fengtai District, 100050, Beijing, China;Chinese Glioma Genome Atlas Network (CGGA), Beijing, China;

关键词: N;    Glioblastoma;    YTHDF2;    METTL3;    NF-κB activation;   

DOI  :  10.1186/s13045-021-01124-z

来源: Springer

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