Cardiovascular magnetic resonance imaging in children after recovery from symptomatic COVID-19 or MIS-C: a prospective study

Journal of Cardiovascular Magnetic Resonance

Karen Rychlik¹  Cynthia K. Rigsby²  Gregory Webster³  Michael R. Carr³  Joshua D. Robinson⁴  Ami B. Patel⁵  Anne H. Rowley⁵ 

[1] Biostatistics Research Core, Stanley Manne Children’s Research Institute, Chicago, IL, USA;Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA;Department of Medical Imaging, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, USA;Division of Cardiology, Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Box 21, 225 E. Chicago Ave., 60611, Chicago, IL, USA;Division of Cardiology, Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Box 21, 225 E. Chicago Ave., 60611, Chicago, IL, USA;Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA;Division of Infectious Diseases, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, USA;

关键词: Pediatric;    Cardiac magnetic resonance imaging;    SARS-CoV-2;    COVID-19;    MIS-C;   

DOI  :  10.1186/s12968-021-00786-5

来源: Springer

【 摘 要 】

BackgroundCardiac evaluations, including cardiovascular magnetic resonance (CMR) imaging and biomarker results, are needed in children during mid-term recovery after infection with SARS-CoV-2. The incidence of CMR abnormalities 1–3 months after recovery is over 50% in older adults and has ranged between 1 and 15% in college athletes. Abnormal cardiac biomarkers are common in adults, even during recovery.MethodsWe performed CMR imaging in a prospectively-recruited pediatric cohort recovered from COVID-19 and multisystem inflammatory syndrome in children (MIS-C). We obtained CMR data and serum biomarkers. We compared these results to age-matched control patients, imaged prior to the SARS-CoV-2 pandemic.ResultsCMR was performed in 17 children (13.9 years, all ≤ 18 years) and 29 age-matched control patients without SARS-CoV-2 infection. Cases were recruited with symptomatic COVID-19 (11/17, 65%) or MIS-C (6/17, 35%) and studied an average of 2 months after diagnosis. All COVID-19 patients had been symptomatic with fever (73%), vomiting/diarrhea (64%), or breathing difficulty (55%) during infection. Left ventricular and right ventricular ejection fractions were indistinguishable between cases and controls (p = 0.66 and 0.70, respectively). Mean native global T1, global T2 values and segmental T2 maximum values were also not statistically different from control patients (p ≥ 0.06 for each). NT-proBNP and troponin levels were normal in all children.ConclusionsChildren prospectively recruited following SARS-CoV-2 infection had normal CMR and cardiac biomarker evaluations during mid-term recovery. Trial Registration Not applicable.

【 授权许可】

CC BY