A cross sectional study to compare cardiac structure and diastolic function in adolescents and young adults with youth-onset type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth Study

Cardiovascular Diabetology

Lynne Wagenknecht¹  Scott Isom¹  Ralph D’Agostino¹  Angela D. Liese²  Amy S. Shah³  Elaine M. Urbina³  Lawrence M. Dolan³  Cate Pihoker⁴  Jean M. Lawrence⁵  Sharon Saydah⁶  Giuseppina Imperatore⁶  Dana Dabelea⁷ 

[1] Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, USA;Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, USA;Department of Pediatrics, Division of Endocrinology, Cincinnati Children’s Hospital Medical Center and The University of Cincinnati, 3333 Burnet Ave ML 7012, 45229, Cincinnati, OH, USA;Department of Pediatrics, The University of Washington, Washington, USA;Department of Research & Evaluation, Kaiser Permanente Southern California, Los Angeles, USA;Division of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, USA;Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus (CU-Anschutz), Aurora, USA;

关键词: Type 1 diabetes;    Type 2 diabetes;    Cardiac structure;    Diastolic function;    Pediatrics;    Young adults;   

DOI  :  10.1186/s12933-021-01328-0

来源: Springer

【 摘 要 】

AimsTo compare left ventricular structure (LV) and diastolic function in young adults with youth- onset diabetes by type, determine the prevalence of abnormal diastolic function by diabetes type using published values from age similar healthy controls, and examine the risk factors associated with diastolic function.MethodsIn a cross sectional analysis we compared LV structure and diastolic function from two dimensional echocardiogram in participants with type 1 (T1D) and type 2 diabetes (T2D) who participated in the SEARCH for Diabetes in Youth Study. Linear models were used to examine the risk factors associated with worse diastolic function.ResultsOf 479 participants studied, 258 had T1D (mean age 21.2 ± 5.2 years, 60.5% non-Hispanic white, 53.9% female) and 221 had T2D (mean age 24.8 ± 4.3 years, 24.4% non-Hispanic white, 73.8% female). Median diabetes duration was 11.6 years. Participants with T2D had greater LV mass index and worse diastolic function that persisted after adjustment for differences in risk factors compared with participants with T1D (all p < 0.05). Abnormal diastolic function, quantified using healthy controls, was pronounced in both groups but greater in those with T2D than T1D (T2D: 57.7% vs T1D: 47.2%, respectively), p < 0.05. Risk factors associated with worse diastolic function included older age at diabetes diagnosis, female sex, higher BP, heart rate and HbA1c and longer diabetes duration.ConclusionsLV structure and diastolic function is worse in individuals with T2D compared to T1D. However, abnormal diastolic function in seen in both groups compared to published values from age similar healthy controls.

【 授权许可】

CC BY