Evaluation of the effect of probiotic as add-on therapy with conventional therapy and alone in malaria induced mice

BMC Research Notes

Alka Bhatia¹  Shweta Sinha²  Rakesh Sehgal²  Eshani Mahajan³  Bikash Medhi³ 

[1] Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, 160012, Chandigarh, India;Department of Medical Parasitology, Postgraduate Institute of Medical Education and Research, 160012, Chandigarh, India;Department of Pharmacology, Postgraduate Institute of Medical Education & Research, Research Block B, 4th Floor, Room no 4043, 160012, Chandigarh, India;

关键词: Chloroquine;    Probiotic;    Malaria;    Lactobacillus casei;   

DOI  :  10.1186/s13104-021-05661-1

来源: Springer

【 摘 要 】

ObjectiveChloroquine is used as a conventional drug therapy for the treatment of malaria. The existence of resistance to chloroquine shown among various species of Plasmodium leads to the search for more efficacious therapy to treat malaria. Probiotic (Lactobacillus casei) has been tried as an add-on therapy with chloroquine. Probiotics are ingested microorganisms associated with a beneficial effect on humans and other species. The study was done to check the efficacy of L. casei as an add-on therapy along with conventional drug therapy (chloroquine) to treat malaria.ResultsProbiotic in combination with chloroquine showed complete suppression in parasitemia rate. Representation of parasitemia rate was done using mean ± SD. p < 0.05 is considered as statistically significant. The results showed a reduction in parasitemia with probiotic treatment, which was further confirmed through histological observation of two major organs, the liver and spleen. Interestingly, further suppression of parasitemia and hemosiderosis was observed when probiotic was given along with chloroquine.

【 授权许可】

CC BY