Sorption of selected antiparasitics in soils and sediments

Environmental Sciences Europe

Abdelmalek Dahchour¹  Rolf-Alexander Düring²  Timm Zöltzer²  Leonard Böhm²  Andre Patrick Heinrich²  Manuel Wohde²  Yassine El Maataoui³  Sara Jaddoudi³ 

[1] Département Des Sciences Fondamentales Et Appliquées, Institut Agronomique Et Véterinaire Hassan II, Rabat, Morocco;Institute of Soil Science and Soil Conservation, Research Center for Biosystems, Land Use and Nutrition (iFZ), Justus Liebig University Giessen, Giessen, Germany;Laboratory of Materials, Nanotechnology and Environment (LMNE), Faculty of Sciences, Mohammed V University in Rabat, Av Ibn Battouta Agdal, BP1014, Rabat, Morocco;

关键词: Sorption;    Pharmaceuticals;    Environmental fate;    Environmental distribution;    K;    K;    Moxidectin;    Avermectin;    Desorption;    Africa;   

DOI  :  10.1186/s12302-021-00513-y

来源: Springer

【 摘 要 】

BackgroundVeterinary pharmaceuticals can enter the environment when excreted after application and burden terrestrial and aquatic ecosystems. However, knowledge about the basic process of sorption in soils and sediments is limited, complicating regulatory decisions. Therefore, batch equilibrium studies were conducted for the widely used antiparasitics abamectin, doramectin, ivermectin, and moxidectin to add to the assessment of their environmental fate.ResultsWe examined 20 soil samples and six sediments from Germany and Morocco. Analysis was based on HPLC-fluorescence detection after derivatization. For soils, this resulted in distribution coefficients KD of 38–642 mL/g for abamectin, doramectin, and ivermectin. Moxidectin displayed KD between 166 and 3123 mL/g. Normalized to soil organic carbon, log KOC coefficients were 3.63, 3.93, 4.12, and 4.74 mL/g, respectively, revealing high affinity to organic matter of soils and sediments. Within sediments, distribution resulted in higher log KOC of 4.03, 4.13, 4.61, and 4.97 mL/g for the four substances. This emphasizes the diverse nature of organic matter in both environmental media. The results also confirm a newly reported log KOW for ivermectin which is higher than longstanding assumptions. Linear sorption models facilitate comparison with other studies and help establish universal distribution coefficients for the environmental risk assessment of veterinary antiparasitics.ConclusionsSince environmental exposure affects soils and sediments, future sorption studies should aim to include both matrices to review these essential pharmaceuticals and mitigate environmental risks from their use. The addition of soils and sediments from the African continent (Morocco) touches upon possible broader applications of ivermectin for human use. Especially for ivermectin and moxidectin, strong sorption further indicates high hydrophobicity and provides initial concern for potential aquatic or terrestrial ecotoxicological effects such as bioaccumulation. Our derived KOW estimates also urge to re-assess this important regulatory parameter with contemporary techniques for all four substances.Graphic abstract

【 授权许可】

CC BY