Atherogenic index of plasma is related to coronary atherosclerotic disease in elderly individuals: a cross-sectional study

Lipids in Health and Disease

Lamei Li¹  Ganwei Shi¹  Feng Li¹  Jianqiang Xiao¹  Gaojun Cai¹  Haomin Huang¹  Zhihua Yun²  Xiaolong Yu³ 

[1] Department of Cardiology, Wujin Hospital Affiliated with Jiangsu University, The Wujin Clinical College of Xuzhou Medical University, Changzhou City, Jiangsu Province, China;Department of Clinical Laboratory, Wujin Hospital Affiliated with Jiangsu University, The Wujin Clinical College of Xuzhou Medical University, Changzhou City, Jiangsu Province, China;Department of Ultrasound, Wujin Hospital Affiliated with Jiangsu University, The Wujin Clinical College of Xuzhou Medical University, Changzhou City, Jiangsu Province, China;

关键词: Atherogenic index of plasma;    Coronary atherosclerotic disease;    Elderly;    Lipid metabolism;    Atherosclerosis;    Cross-sectional study;   

DOI  :  10.1186/s12944-021-01496-8

来源: Springer

【 摘 要 】

BackgroundDyslipidaemia plays an important role in coronary atherosclerotic disease (CAD). The relationship between the atherogenic index of plasma (AIP) and CAD in elderly individuals was explored in this study.MethodsElderly individuals (age ≥ 65 years) who underwent coronary angiography from January 2016 to October 2020 were consecutively enrolled in the study.ResultsA total of 1313 individuals, including 354 controls (non-CAD) and 959 CAD patients, were enrolled. In univariate analysis of all populations, the adjusted AIP (aAIP) in the CAD group was 1.13 (0.96, 1.3), which was significantly higher than that in the controls [1.07 (0.89, 1.26)]. However, in subgroup analyses, this phenomenon was only present in males. In addition, further study showed that aAIP was positively related to CAD severity. In binary logistic regression analyses, after adjusting for sex, age, smoking status, primary hypertension (PH), type 2 diabetes mellitus (T2DM), heart rate (HR), white blood cell (WBC) and platelet (PLT), AIP remained independently related to CAD in elderly individuals and was superior to traditional and other nontraditional lipid indices. Subgroup analyses showed that AIP independently influenced CAD risk in males. Ultimately, sensitivity analyses were performed excluding all coronary emergencies, and the final results were similar.ConclusionsAIP was positively related to the risk and severity of CAD in elderly individuals and was superior to traditional and other nontraditional lipid profiles. However, this association only exists in elderly males.

【 授权许可】

CC BY