The evolutionary arms race between transposable elements and piRNAs in Drosophila melanogaster

BMC Evolutionary Biology

article

Luo, Shiqi¹  Zhang, Hong¹  Duan, Yuange¹  Yao, Xinmin¹  Clark, Andrew G.³  Lu, Jian¹ 

[1] State Key Laboratory of Protein and Plant Gene Research, Center for Bioinformatics, College of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University;College of Plant Protection, Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University;Department of Molecular Biology and Genetics, Cornell University

关键词: Transposable element;    piRNA;    Arms race;    Co-evolution;    Drosophila melanogaster;   

DOI  :  10.1186/s12862-020-1580-3

学科分类：护理学

来源: BioMed Central

【 摘 要 】

The piwi-interacting RNAs (piRNAs) are small non-coding RNAs that specifically repress transposable elements (TEs) in the germline of Drosophila. Despite our expanding understanding of TE:piRNA interaction, whether there is an evolutionary arms race between TEs and piRNAs was unclear. Here, we studied the population genomics of TEs and piRNAs in the worldwide strains of D. melanogaster. By conducting a correlation analysis between TE contents and the abundance of piRNAs from ovaries of representative strains of D. melanogaster, we find positive correlations between TEs and piRNAs in six TE families. Our simulations further highlight that TE activities and the strength of purifying selection against TEs are important factors shaping the interactions between TEs and piRNAs. Our studies also suggest that the de novo generation of piRNAs is an important mechanism to repress the newly invaded TEs. Our results revealed the existence of an evolutionary arms race between the copy numbers of TEs and the abundance of antisense piRNAs at the population level. Although the interactions between TEs and piRNAs are complex and many factors should be considered to impact their interaction dynamics, our results suggest the emergence, repression specificity and strength of piRNAs on TEs should be considered in studying the landscapes of TE insertions in Drosophila. These results deepen our understanding of the interactions between piRNAs and TEs, and also provide novel insights into the nature of genomic conflicts of other forms.

【 授权许可】

CC BY|CC0