Evaluation of glucose tolerance and effect of dietary management on increased visceral fat in a patient with Werner syndrome

Endocrine journal

article

Reina Yamamoto¹  Seiichiro Kurita¹  Kyota Akasaki¹  Masataka Horita¹  Makoto Yonezawa¹  Hiroki Asakura¹  Takehiro Kanamori¹  Yoshiro Maezawa²  Masaya Koshizaka²  Koutaro Yokote² 

[1] Department of Endocrinology and Metabolism, National Hospital Organization Kanazawa Medical Center;Department of Endocrinology, Chiba University Graduate School of Medicine

关键词: Werner syndrome;    Diabetes mellitus;    Visceral fat;    Insulin resistance;    Insulin secretion;   

DOI  :  10.1507/endocrj.EJ20-0304

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

Werner syndrome (WS), a type of progeria, is a hereditary condition caused by a mutation in the WRN gene. A 62-year-old Japanese woman was diagnosed with WS at the age of 32 and has been visiting the hospital for follow-up since the last 30 years. The patient developed diabetes at the age of 46, and at the age of 60, her body mass index increased from 20.1 to 22.7 kg/m 2 owing to her unhealthy eating habits; her visceral fat area at the age of 61 was 233 cm 2 . With dietary control, her body weight, including the visceral fat and subcutaneous fat, decreased at the age of 62, and her insulin secretion, obesity, and fatty liver improved. We conducted the oral glucose challenge test four times, including at the prediabetic stage, to evaluate the insulin-secretion ability. The patient’s insulin resistance gradually increased for more than 14 years, and her insulin secretion ability began to decrease 14 years after her diabetes diagnosis. Despite a remarkable decrease in body weight and fat mass with dietary management, the psoas muscle index did not decrease significantly in proportion to the body weight or fat mass. However, muscle mass monitoring is important for preventing the progression of sarcopenia. Hence, gradual reduction of visceral fat and weight by dietary management may be useful in treating diabetes in patients with WS, particularly in those whose visceral fat is significantly increased.

【 授权许可】

Unknown