New models of adipogenic differentiation highlight a cell-autonomous response to temperature

Biocell

article

KSENIJA VELICKOVIC¹  HILDA ANAID LUGO LEIJA¹  SARAH MCGINLAY¹  MICHAEL E. SYMONDS¹  VIRGINIE SOTTILE¹ 

[1] School of Medicine, The University of Nottingham;Faculty of Biology, The University of Belgrade;The Early Life Research Unit, Academic Division of Child Health, and Nottingham Digestive Disease Centre and Biomedical Research Centre, The School of Medicine, The University of Nottingham;Department of Molecular Medicine, The University of Pavia

关键词: Adipose tissue;    Cell differentiation;    Temperature;    Cell autonomous response;    Transient receptor potential (TRP) channels;   

DOI  :  10.32604/biocell.2020.012942

学科分类：仪器

来源: Biocell

【 摘 要 】

Temperature is a key regulator of brown adipose tissue (BAT) function, acting through central sensory inputs to influence metabolism and energy storage. Although animal models have produced a wealth of information on the pathways, effectors and responses mediating the physiological response of adipose tissue to temperature in vivo, the use of cell culture models now offers evidence of an additional cell-autonomous response to temperature changes, in the absence of neural input. In particular, stem cell models provide new insight into the regulation of adipogenic differentiation and the induction of browning features in vitro . Here the basis for adipogenic responsiveness to low temperature is discussed, together with different human cell models available to outline the benefits of cell-based approaches for future BAT research.

【 授权许可】

CC BY