Piceatannol attenuates streptozotocin-induced type 1 diabetes in mice

Biocell

article

MENGSHU ZHAO¹  JIANFA ZHANG¹  DAN WENG¹  PINGSHI GAO¹  LIANG TAO¹  JINGJING WEN¹  LEI WANG¹  YUGUO YI¹  YUXIN CHEN²  JUNSONG WANG¹  XI XU¹ 

[1] School of Environmental and Biological Engineering, Nanjing University of Science & Technology;Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School

关键词: Piceatannol;    Type 1 diabetes;    Streptozotocin;    Oxidative stress;    Inflammation;    ER stress;   

DOI  :  10.32604/biocell.2020.08955

学科分类：仪器

来源: Biocell

【 摘 要 】

As a natural analog of resveratrol, piceatannol (Pic) exhibits good antioxidant and anti-inflammatory activities in different disease models. However, the role of Pic in type 1 diabetes mouse model has not been reported yet. In this study, we investigated the in vivo effect of Pic in streptozotocin (STZ)-induced type 1 diabetic mice. Mice were injected with STZ to establish the type 1 diabetes mellitus (T1DM) model. After stable hyperglycemia was achieved, mice were then orally treated with Pic (40 mg/kg b.w., i.g.) for 30 days. The results indicated that Pic supplementation efficiently alleviated the typical symptoms associated with T1DM, including body weight loss, polydipsia, hyperglycemia, and hypoinsulinemia. Pic treatment also improved the glucose tolerance of STZ-induced diabetic mice. In addition, Pic supplementation markedly decreased the expression of pro-inflammatory molecules TNF-α and IL-6, the expression of endoplasmic reticulum (ER) stress markers GRP78 and CHOP, and the level of oxidative stress in T1DM mice. Moreover, Pic administration also partly reversed the metabolic profiles of STZ-treated mice as detected by 1 H Nuclear Magnetic Resonance (NMR)-based metabolomics. Our study suggested that the therapeutic potential of Pic in type 1 diabetes and the anti-diabetic effects of Pic may be associated with its activities to suppress oxidative stress, inflammation, and ER stress.

【 授权许可】

CC BY