Daily amylin replacement reverses hepatic glycogen depletion in insulin‐treated streptozotocin diabetic rats

FEBS Letters

Crocker, Leslie B.¹  Wolfe-Lopez, Deborah¹  Cooper, Garth J.S.¹  Young, Andrew A.¹ 

[1] Department of Physiology, Amylin Corporation, 9373 Towne Centre Drive, San Diego, CA 921221, USA

关键词: Amylin;    Insulin;    Cori cycle;    Counterregulation;    Streptozotocin;    Type 1 diabetes;   

DOI  :  10.1016/0014-5793(91)80051-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In streptozotocin-diabetic rats treated with insulin replacement, liver glycogen is some 35% depleted. Five consecutive daily subcutaneous injections with amylin dose-dependently restored liver glycogen to normal levels. Significant increases over insulin-only therapy occurred with amylin doses of 10, 30 and 100 , representing amylin: insulin ratios of 0.22. 0.75 and 2.79.

【 授权许可】

Unknown