Role of pyroptotic cell death in the pathogenesis of NASH

Biocell

article

Yuguo YI¹  Jiamin ZHENG¹  Yang ZHOU¹  Zhiqin LIU¹  Dan WENG¹ 

[1] Center for Molecular Metabolism, Nanjing University of Science & Technology

关键词: Gasdermin-D;    Non-alcoholic fatty liver disease;    Pyroptosis;    Steatohepatitis;   

DOI  :  10.32604/biocell.2020.08686

学科分类：仪器

来源: Biocell

【 摘 要 】

Nonalcoholic fatty liver disease (NAFLD) represents a huge threat to public health of the whole world. Around 25% of NAFLD patients will progress to nonalcoholic steatohepatitis (NASH), which has been predicted to be the main reason for liver transplantation in the United States in 2020. Extensive effort has been devoted to investigating the underlying molecular mechanisms of NASH pathogenesis and developing new promising treatments. Recent studies have demonstrated that pyroptosis, an inflammatory programmed cell death mediated by inflammasome and gasdermin-D (GSDMD), is involved in the development and progression of NASH. This review aims to summarize the recent findings regarding the role of pyroptosis and related molecules in the pathogenesis of NASH.

【 授权许可】

CC BY