Early mortality from malignant mesothelioma in Italy as a proxy of environmental exposure to asbestos in children

Annali dell'Istituto superiore di sanita

article

Lucia Fazzo¹  Alessandro Marinaccio²  Ivano Iavarone¹  Giada Minelli¹  Caterina Bruno¹  Pietro Comba¹  Susanna Conti¹  Marco De Santis¹  Amerigo Zona¹  Alessandra Binazzi²  Corrado Magnani³ 

[1] Istituto Superiore di Sanità;Istituto Nazionale per l'Assicurazione contro gli Infortuni sul Lavoro;Università del Piemonte Orientale

关键词: epidemiology;    mesothelioma;    mortality;    asbestos;    young adults;   

DOI  :  10.4415/ANN_20_04_10

学科分类：社会科学、人文和艺术（综合）

来源: Istituto Superiore di Sanita

【 摘 要 】

Malignant mesothelioma (MM) is a rare neoplasm caused by asbestos. Mortality from MM in ≤50 years old people, considering the long latency, is likely related to asbestos exposure in childhood. Mortality from MM (C45, ICD10 code) is described among ≤50 years (ys) old people in Italy, in 2003-2016. National and regional Standardized Rates (SRs) were computed by age-class. The North-South trend of regional SRs, increasing in >50ys age-class, showed a flat cline in ≤50ys old people. Municipal Standardized Mortality Ratios (SMRs) were computed, with respect to regional figures, for ≤50 ys old population. In Italy, 487 people ≤50 ys old died from MM, in 2003-2016 (2.5% of all MM deaths), corresponding to 35/year. The highest SMRs were observed in Northern Regions, the most industrialized areas. Exceeding SMRs were found in 10 municipalities where former asbestos-cement plants, shipyards, and a quarry contaminated by fluoroedenite fibres were present. Early mortality from MM, proxy of childhood environmental asbestos exposure, deserves particular concern.

【 授权许可】

CC BY-NC-ND