A study of diffusion tensor imaging of median nerve in diabetic peripheral neuropathy

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

article

Edward, Ramy¹  Abdelalim, Ahmed M.²  Ashour, Amal S.²  Afifi, Lamia³  Al-Athwari, Aussan² 

[1] Department of Radiodiagnosis, Cairo University;Department of Neurology, Cairo University;Clinical Neurophysiology Unit, Cairo University

关键词: Diabetic neuropathy;    DTI;    FA;    ADC;    Clinical scores;    NCS;   

DOI  :  10.1186/s41983-020-00172-5

学科分类：医学（综合）

来源: Springer

【 摘 要 】

To evaluate the role of diffusion tensor imaging (DTI) in the evaluation of diabetic peripheral neuropathy (DPN) compared to clinical scores and nerve conduction studies (NCS). We included 30 patients with diabetes mellitus complaining of neuropathy symptoms and 15 healthy volunteers. All subjects underwent evaluation using 1.5-T DTI of median nerves and NCS. Patients underwent clinical evaluation using the Neuropathy Deficit Score (NDS), Neuropathy Impairment Score in the Lower Limbs (NIS-LL), and Diabetic Neuropathy Examination (DNE) score. We found statistically significant differences between healthy volunteers and patients in fractional anisotropy (FA) of the distal segment (P = 0.016) and whole median nerve (P = 0.024), apparent diffusion coefficient (ADC) of proximal (P = 0.027) and distal (P < 0.001) segments, and whole median nerve (P = 0.019). Distal segment FA was significantly correlated with NDS (P = 0.003), DNEs (P = 0.003), sensory amplitude (P = 0.048), and motor CV (P = 0.020). Distal segment ADC was significantly correlated with NDS (P = 0.007), NIS-LL (P = 0.003), DNEs (P = 0.01), and sensory amplitude (P = 0.032). The best cut-off value of distal segment for FA was 0.45 (87% sensitivity, 80% specificity) and of distal segment ADC was 1.217 (80% sensitivity and specificity). Our results suggest that 1.5-T DTI examination of the median nerve can provide useful non-invasive information in patients with DPN. ClinicalTrials.gov, NCT03934970. Registered on May 1, 2019

【 授权许可】

CC BY