Blisters on your fingers

Journal of Cell Communication and Signaling

article

Leask, Andrew¹ 

[1] College of Dentistry, University of Saskatchewan

关键词: Microenvironment;    Scleroderma;    Systemic sclerosis;    Coculture;    Fibrosis;    Myofibroblast;    Stem cells;   

DOI  :  10.1007/s12079-021-00626-2

学科分类：分子生物学，细胞生物学和基因

来源: Springer

【 摘 要 】

Mesenchymal progenitor cells play a key role in fibrogenesis. An exciting paper was recently published showed that blister fluid from the skin patients with the autoimmune connective tissue disease scleroderma (systemic sclerosis, SSc) preferentially activated mesenchymal progenitor cells (Taki et al. in Arthritis Rheumatol 72(8):1361–1374, 2020). These data provide new and invaluable insights into the complex interactions in the connective tissue microenvironment that ultimately result in persistent, pathological fibrosis.

【 授权许可】

CC BY