Regulation of bone morphogenetic protein 4 on epithelial tissue

Journal of Cell Communication and Signaling

article

Shen, Sitong¹  Wang, Shurong¹  He, Yuxi¹  Hu, Huicong¹  Yao, Boyuan¹  Zhang, Yan¹ 

[1] Department of Ophthalmology, the 2nd Hospital of Jilin University

关键词: Bone morphogenetic protein 4;    Epithelial tissue;    Growth and differentiation;    Benign lesions;    Cancer;   

DOI  :  10.1007/s12079-019-00537-3

学科分类：分子生物学，细胞生物学和基因

来源: Springer

【 摘 要 】

Epithelial tissues provide tissue barriers and specialize in organs and glands. When epithelial homeostasis is physiologically or pathologically stimulated, epithelial cells produce mesenchymal cells through the epithelial-mesenchymal transition, forming new tissues, promoting the cure of diseases or leading to illness. A variety of cytokines are involved in the regulation of epithelial cell differentiation. Bone morphogenetic proteins (BMPs), especially the bone morphogenetic protein 4 (BMP4) has a variety of biological functions and plays a prominent role in the regulation of epithelial cell differentiation. BMP4 is an important regulatory factor of a series of life activities in vertebrates, which is also related to cell proliferation, differentiation and mobility, it also has relation with tumor development. This paper mainly reviews the mechanism of BMP4’s regulation on epithelial tissues, as well as its effect on the growth, differentiation, benign lesions and malignant lesions of epithelial tissues, and expounds the function of BMP4 in epithelial tissues, to provide theoretical support for the research on reducing epithelial diseases.

【 授权许可】

CC BY