The Relationship of the TLR9 and TLR2 Genetic Polymorphisms with Cervical Cancer Risk: a Meta-Analysis of Case-Control Studies

Pathology oncology research: POR

article

Yang, Shasha¹  Liu, Lan²  Xu, Dongyuan¹  Li, Xiangdan¹ 

[1] Center of Morphological Experiment, Medical College of Yanbian University;Department of pathology, Affiliated Hospital of Yanbian University

关键词: TLR9;    TLR2;    Meta-analysis;    Cervical cancer;    Polymorphism;   

DOI  :  10.1007/s12253-018-0465-x

来源: Springer

【 摘 要 】

This meta-analysis aimed to assess the association of common TLR9 and TLR2 gene polymorphisms (TLR9 1486 T/C, TLR9 G2848A, and TLR2–196 to −174 del/ins) with cervical cancer risk. Studies were searched in Scopus, Pubmed, Embase, and CNKI until December 2017. Both fixed-effects and random-effects models were applied to combine odds ratio (OR) and 95% confidence intervals (95% CI). A total of 11 studies including 7856 participants were identified. The pooled estimation revealed an increased risk of cervical cancer in Caucasian subjects carrying the C allele of the TLR9 1486 T/C polymorphism (OR = 1.46, 95% CI: 1.11–1.92, p = 0.007), while there was a decreased risk in Mixed subjects carrying the C allele (OR = 0.35, 95% CI: 0.15–0.82, p = 0.016). Concerning the TLR9 G2848A polymorphism, the A allele was associated with an increased risk of cervical cancer in Caucasians (OR = 1.19, 95% CI: 1.02–1.40, p = 0.030), whereas Asian and Mixed subjects showed no significant associations. No significant associations were demonstrated between the TLR2–196 to −174 del/ins polymorphism and cervical cancer. Our findings suggest that the TLR9 1486 T/C and G2848A polymorphisms contribute to cervical cancer risk, but there is no association of the TLR2–196 to −174 del/ins polymorphism with cervical cancer.

【 授权许可】

Unknown