Psychosocial experiences modulate asthma-associated genes through gene-environment interactions

eLife

Henriette Mair-Meijers¹  Adnan Alazizi¹  Justyna A Resztak¹  Francesca Luca²  Roger Pique-Regi²  Derek E Wildman³  Xiaoquan Wen⁴  Allison K Farrell⁵  Richard B Slatcher⁶  Samuele Zilioli⁷ 

[1] Center for Molecular Medicine and Genetics, Wayne State University, Detroit, United States;Center for Molecular Medicine and Genetics, Wayne State University, Detroit, United States;Department of Obstetrics and Gynecology, Wayne State University, Detroit, United States;College of Public Health, University of South Florida, Tampa, United States;Department of Biostatistics, University of Michigan, Ann Arbor, United States;Department of Psychology, Miami University, Oxford, United States;Department of Psychology, Wayne State University, Detroit, United States;Department of Psychology, Wayne State University, Detroit, United States;Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, United States;

关键词: eQTLs;    gene expression;    GxE;    asthma;    Human;   

DOI  :  10.7554/eLife.63852

来源: eLife Sciences Publications, Ltd

【 摘 要 】

Social interactions and the overall psychosocial environment have a demonstrated impact on health, particularly for people living in disadvantaged urban areas. Here, we investigated the effect of psychosocial experiences on gene expression in peripheral blood immune cells of children with asthma in Metro Detroit. Using RNA-sequencing and a new machine learning approach, we identified transcriptional signatures of 19 variables including psychosocial factors, blood cell composition, and asthma symptoms. Importantly, we found 169 genes associated with asthma or allergic disease that are regulated by psychosocial factors and 344 significant gene-environment interactions for gene expression levels. These results demonstrate that immune gene expression mediates the link between negative psychosocial experiences and asthma risk.

【 授权许可】

CC BY