Circulating ERBB3 levels are inversely associated with the risk of overweight-related hypertension: a cross-sectional study

BMC Endocrine Disorders

Mengyun Huang¹  Yan Chen²  Lijun Zhu²  Weiwei Chang²  Zhengmei Fang²  Yuelong Jin²  Yingshui Yao³ 

[1] Department of Epidemiology and Biostatistics, School of Public Health, Wannan Medical College, No. 22, Wenchang Road, 241002, Wuhu, Anhui, China;Department of Epidemiology and Biostatistics, School of Public Health, Wannan Medical College, No. 22, Wenchang Road, 241002, Wuhu, Anhui, China;Institute of Chronic Disease Prevention and Control,Wannan Medical College, No. 22, Wenchang Road, 241002, Wuhu, Anhui, China;Department of Epidemiology and Biostatistics, School of Public Health, Wannan Medical College, No. 22, Wenchang Road, 241002, Wuhu, Anhui, China;Institute of Chronic Disease Prevention and Control,Wannan Medical College, No. 22, Wenchang Road, 241002, Wuhu, Anhui, China;Department of Medicine, Anhui College of Traditional Chinese Medicine, No.18, Wuxia Shanxi Road, 241003, Wuhu, Anhui, China;

关键词: ERBB3;    Hypertension;    Overweight;    Body mass index;   

DOI  :  10.1186/s12902-021-00793-8

来源: Springer

【 摘 要 】

BackgroundHypertension and overweight are independent risk factors for cardiovascular disease, and overweight increase the risk of developing high blood pressure. ERBB3( also known as HER3) plays a considerable role in the development of cardiovascular diseases. However, the effect of ERBB3 levels in hypertensive overweight patients is unknown. The aim of this study was to assess the association between ERBB3 levels and hypertension in overweight Chinese patients.MethodsWe evaluated the height,weight, blood pressure, biochemical indicators, and ERBB3 levels in 128 Chinese adults aged 33–79 years. Plasma ERBB3 levels were assessed by the enzyme-linked immunosorbent assay, and body mass index(BMI) was calculated as body weight divided by height squared. Participants were allocated into three groups according to blood pressure and BMI: healthy control (CNT, n = 31; normotensive and non-overweight), hypertension (HT, n = 33; hypertension and non-overweight), and hypertension with overweight (HTO, n = 64; hypertension and overweight). Statistical significance was defined as a two-tailed P < 0.05.ResultsThere was no significant difference in mean ERBB3 levels among the three groups, although a linear decrease from CNT (1.13 ± 0.36), HT (1.03 ± 0.36), to HTO (0.84 ± 0.26 ng/mL) was observed in men (P = 0.007). Among the drinking population, the ERBB3 level was significantly reduced in the HTO group as compared with those of the CNT and HT groups (0.76 ± 0.23 versus 1.18 ± 0.37 and 1.20 ± 0.30, respectively). ERBB3 levels were negatively correlated with diastolic blood pressure in men (r= − 0.293, P = 0.012), smoking (r= − 0.47, P = 0.004), and drinking (r = − 0.387, P = 0.008). BMI in men and among drinkers, and uric acid among drinkers were negatively correlated with ERBB3 levels. Multivariate conditional logistic regression showed that plasma ERBB3 levels were associated with a reduced risk of HTO in men [odds ratio (OR) 0.054; 95 % confidence interval (CI): 0.007–0.412) and drinkers (OR 0.002; 95 % CI: 0.000–0.101).ConclusionsERBB3 may contribute to the pathogenesis of hypertension in overweight patients, with BMI, gender, and drinking all potentially modulating the process.

【 授权许可】

CC BY