Information flow, cell types and stereotypy in a full olfactory connectome

eLife

Asa Barth-Maron¹  Tomke Stürner²  Elizabeth C Marin²  Imaan FM Tamimi²  Sridhar R Jagannathan²  Laia Serratosa Capdevila²  Nikolas Drummond²  Alexandre Javier²  Marta Costa²  Joseph Hsu³  Feng Li⁴  Gerald M Rubin⁴  Stephen M Plaza⁴  Alexander Shakeel Bates⁵  Philipp Schlegel⁶  Gregory S X E Jefferis⁶ 

[1] Department of Neurobiology, Harvard Medical School, Boston, United States;Department of Zoology, University of Cambridge, Cambridge, United Kingdom;Department of Zoology, University of Cambridge, Cambridge, United Kingdom;Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States;Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States;Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom;Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom;Department of Zoology, University of Cambridge, Cambridge, United Kingdom;

关键词: connectomics;    olfaction;    stereotypy;    neuroanatomy;    synapses;    Drosophila;    D. melanogaster;   

DOI  :  10.7554/eLife.66018

来源: eLife Sciences Publications, Ltd

【 摘 要 】

The hemibrain connectome provides large-scale connectivity and morphology information for the majority of the central brain of Drosophila melanogaster. Using this data set, we provide a complete description of the Drosophila olfactory system, covering all first, second and lateral horn-associated third-order neurons. We develop a generally applicable strategy to extract information flow and layered organisation from connectome graphs, mapping olfactory input to descending interneurons. This identifies a range of motifs including highly lateralised circuits in the antennal lobe and patterns of convergence downstream of the mushroom body and lateral horn. Leveraging a second data set we provide a first quantitative assessment of inter- versus intra-individual stereotypy. Comparing neurons across two brains (three hemispheres) reveals striking similarity in neuronal morphology across brains. Connectivity correlates with morphology and neurons of the same morphological type show similar connection variability within the same brain as across two brains.

【 授权许可】

CC BY