Hematological indices and abnormalities among patients with uncomplicated falciparum malaria in Kosti city of the White Nile state, Sudan: a comparative study

BMC Infectious Diseases

Omnia A. M. Alhasan¹  Aboagla KhirAlla¹  Fatin A. DfaAlla¹  Nada Y. Ali¹  Rashad Abdul-Ghani²  Abdelhakam G. Tamomh³  Moataz M. Ali⁴  Elsharif A. Bazie⁵  Ahmed M. E. Elkhalifa⁶  Nur Eldin Eltaher⁷ 

[1] Department of Hematology, Faculty of Medical Laboratory Sciences, University of El Imam El Mahdi, Kosti, Sudan;Department of Medical Parasitology, Faculty of Medicine and Health Sciences, Sana’a University, Sana’a, Yemen;Tropical Disease Research Center, Faculty of Medicine and Health Sciences, University, of Science and Technology, Sana’a, Yemen;Department of Parasitology and Medical Entomology, Faculty of Medical Laboratory Sciences, University of El Imam El Mahdi, Kosti, Sudan;Department of Pathology, Faculty of Medicine, University of El Imam El Mahdi, Kosti, Sudan;Department of Pathology, Faculty of Medicine, Albaha University, Albaha, Kingdom of Saudi Arabia;Department of Pediatrics, Faculty of Medicine, University of El Imam El Mahdi, Kosti, Sudan;Department of Public Health, College of Health Sciences Saudi Electronic University, Riyadh, Kingdom of Saudi Arabia;Department of Hematology, Faculty of Medical Laboratory Sciences, University of El Imam El Mahdi, Kosti, Sudan;Department of Public Health, Faculty of Public and Environmental Health, University of El Imam El Mahdi, Kosti, Sudan;

关键词: Falciparum malaria;    Hematological indices;    Anemia;    Thrombocytopenia;    Neutropenia;    MCV;    MCH;    MCHC;    RDW;    Sudan;   

DOI  :  10.1186/s12879-021-06228-y

来源: Springer

【 摘 要 】

BackgroundHematological abnormalities are common features in falciparum malaria but vary among different populations across countries. Therefore, we compared hematological indices and abnormalities between Plasmodium falciparum-infected patients and malaria-negative subjects in Kosti city of the White Nile State, Sudan.MethodsA comparative, cross-sectional study was conducted at the Clinical Laboratory Unit of Kosti Teaching Hospital from June to December 2018. A total of 392 participants (192 P. falciparum-infected patients and 200 malaria-negative subjects) were recruited in the study. Hematological indices of hemoglobin (Hb), red blood cells (RBCs), white blood cells (WBCs) and platelets were measured, and their median values were statistically compared.ResultsThe majority of P. falciparum-infected patients (67.6%) showed a low-level parasitemia. The median values of Hb concentration, RBC count, mean corpuscular volume (MCV), mean corpuscular Hb (MCH) and mean corpuscular Hb concentration (MCHC) were significantly lower in P. falciparum-infected patients, while the median red cell distribution width (RDW) was significantly higher in the patients compared to malaria-negative subjects. Anemia, low MCV, low MCH, low MCHC and high RDW were significantly associated with falciparum malaria, but parasitemia level was not significantly associated with anemia severity. The median total WBC count was non-significantly higher in P. falciparum-infected patients, with neutropenia being significantly associated with falciparum malaria. The median platelet count was significantly lower in P. falciparum-infected patients, with thrombocytopenia being significantly associated with falciparum malaria.ConclusionsFalciparum malaria among patients in Kosti city of the White Nile State, Sudan is predominantly of low-level parasitemia. It is significantly associated with anemia, low MCV, low MCH, low MCHC, high RDW, thrombocytopenia and neutropenia. However, parasitemia level is not a significant predictor of anemia severity. On the other hand, leucopenia is not useful to predict falciparum malaria. Further large-scale studies in community and healthcare settings and inclusion of patients with complicated or severe malaria and those with high parasite densities are recommended.

【 授权许可】

CC BY