Design and system evaluation of a dual-panel portable PET (DP-PET)

EJNMMI Physics

Xu Chu¹  Qun Chen¹  Tianyi Zeng²  Shuangyue Zhang³  Jiaxu Zheng³  Xin Chen³  Xinyuan Xia³  Tuoyu Cao³  Beien Wang³  Adam Chandler⁴  Lingzhi Hu⁴ 

[1] Shanghai Advanced Research Institute, Chinese Academy of Sciences, 201210, Shanghai, China;Shanghai United Imaging Healthcare Co., Ltd., 201807, Shanghai, China;Shanghai Advanced Research Institute, Chinese Academy of Sciences, 201210, Shanghai, China;University of Chinese Academy of Sciences, 100049, Beijing, China;Shanghai United Imaging Healthcare Co., Ltd., 201807, Shanghai, China;United Imaging Healthcare, America, 77054, Houston, TX, USA;

关键词: PET insert;    Potable PET;    MR-compatible PET;    System performance;   

DOI  :  10.1186/s40658-021-00392-5

来源: Springer

【 摘 要 】

BackgroundIntegrated whole-body PET/MR technology continues to mature and is now extensively used in clinical settings. However, due to the special design architecture, integrated whole-body PET/MR comes with a few inherent limitations. Firstly, whole-body PET/MR lacks sensitivity and resolution for focused organs. Secondly, broader clinical access of integrated PET/MR has been significantly restricted due to its prohibitively high cost. The MR-compatible PET insert is an independent and removable PET scanner which can be placed within an MRI bore. However, the mobility and configurability of all existing MR-compatible PET insert prototypes remain limited.MethodsAn MR-compatible portable PET insert prototype, dual-panel portable PET (DP-PET), has been developed for simultaneous PET/MR imaging. Using SiPM, digital readout electronics, novel carbon fiber shielding, phase-change cooling, and MRI compatible battery power, DP-PET was designed to achieve high-sensitivity and high-resolution with compatibility with a clinical 3-T MRI scanner. A GPU-based reconstruction method with resolution modeling (RM) has been developed for the DP-PET reconstruction. We evaluated the system performance on PET resolution, sensitivity, image quality, and the PET/MR interference.ResultsThe initial results reveal that the DP-PET prototype worked as expected in the MRI bore and caused minimal compromise to the MRI image quality. The PET performance was measured to show a spatial resolution ≤ 2.5 mm (parallel to the detector panels), maximum sensitivity = 3.6% at the center of FOV, and energy resolution = 12.43%. MR pulsing introduces less than 2% variation to the PET performance measurement results.ConclusionsWe developed a MR-compatible PET insert prototype and performed several studies to begin to characterize the performance of the proposed DP-PET. The results showed that the proposed DP-PET performed well in the MRI bore and would cause little influence on the MRI images. The Derenzo phantom test showed that the proposed reconstruction method could obtain high-quality images using DP-PET.

【 授权许可】

CC BY