Association between PNPLA3 rs738409 polymorphism and nonalcoholic fatty liver disease: a systematic review and meta-analysis

BMC Endocrine Disorders

Nader Salari¹  Melika Hosseinian-Far²  Masoud Mohammadi³  Kamran Mansouri⁴  Fateme Darvishi⁵  Hooman Ghasemi⁵  Niloufar Darvishi⁵ 

[1] Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran;Department of Food Science & Technology, Faculty of Agriculture, Ferdowsi University of Mashhad (FUM), Kermanshah, Iran;Department of Nursing, School of Nursing and Midwifery, Kermanshah University of Medical Sciences, Kermanshah, Iran;Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran;Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran;

关键词: Polymorphism;    Gene;    Non-alcoholic fatty liver;    NAFLD;    PNPLA3;   

DOI  :  10.1186/s12902-021-00789-4

来源: Springer

【 摘 要 】

BackgroundNon-alcoholic fatty liver disease (NAFLD) is a common disorder that is known to be the leading cause of chronic liver disease worldwide. This study aims to systematically review and meta-analyze the association between PNPLA3 rs738409 polymorphism and non-alcoholic fatty liver.MethodsFollowing a systematic review and meta-analysis method, articles without any time limitation, were extracted from SID, MagIran, IranDoc, Scopus, Embase, Web of Science (WoS), PubMed and ScienceDirect international databases. Random effects model was used for analysis, and heterogeneity of studies was investigated considering the I2 index and using Comprehensive Meta-Analysis software.ResultsThe odds ratio of CC genotype in patients with non-alcoholic fatty liver demonstrates the protective effect of CC genotype with the ratio of 0.52, whereas CG genotype presents an increasing effect of CG genotype with the ratio of 0.19, and GG genotype also showed an increasing effect of GG genotype with the ratio of 1.05. Moreover, CG + GG genotypes as a single group demostrated an odds rartio of 0.88.ConclusionThis meta-analysis highlights that people with CC genotype has 52% lower chance of developing non-alcoholic fatty liver disease, and those with CG genotype had 19% higher risk of developing non-alcoholic fatty liver. Those with GG genotype were 105% more likely to develop non-alcoholic fatty liver than others. Moreover, those present in a population with CG + GG genotypes were 88% more likely to have non-alcoholic fatty liver disease.

【 授权许可】

CC BY