Genetic modifiers of non-alcoholic fatty liver disease progression

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

卷:1812

Review

Anstee, Quentin M.¹  Daly, Ann K.¹  Day, Christopher P.¹ 

[1] Newcastle Univ, Sch Med, Med Sci Fac Off, Liver Res Grp,Inst Cellular Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

关键词: NAFLD;    NASH;    Steatohepatitis;    Gene;    Polymorphism;   

DOI  :  10.1016/j.bbadis.2011.07.017

来源: Elsevier

【 摘 要 】

Non-alcoholic fatty liver disease (NAFLD) is now recognised as the most common cause of liver dysfunction worldwide. However, whilst the majority of individuals who exhibit features of the metabolic syndrome including obesity and insulin resistance will develop steatosis, only a minority progress to steatohepatitis, fibrosis and cirrhosis. Subtle inter-patient genetic variations and environment interact to determine disease phenotype and influence progression. A decade after the sequencing of the human genome, the comprehensive study of genomic variation offers new insights into the modifier genes, pathogenic mechanisms and is beginning to suggest novel therapeutic targets. We review the current status of the field with particular focus on advances from recent genome-wide association studies. (C) 2011 Elsevier B.V. All rights reserved.

【 授权许可】

Free