Sleep and physical activity patterns in adults and children with Bardet–Biedl syndrome

Orphanet Journal of Rare Diseases

Jeffrey J. VanWormer¹  Jeremy Pomeroy²  Robert M. Haws³  Hema R. Murali³  Jill R. Meilahn⁴  Tara Maki⁵ 

[1] Clinical Epidemiology and Population Health, Marshfield Clinic Research Institute, Marshfield, WI, USA;Department of Clinical Research, Marshfield Clinic Research Institute, 1000 North Oak Ave, 54449, Marshfield, WI, USA;Department of Pediatrics, Marshfield Clinic Health System, Marshfield, WI, USA;Department of Physical Medicine, Marshfield Clinic Health System, Marshfield, WI, USA;Physical Therapy Department, Marshfield Clinic Health System, Marshfield, WI, USA;

关键词: Bardet–Biedl syndrome;    Sleep;    Sedentary time;    Physical activity;    Accelerometer;   

DOI  :  10.1186/s13023-021-01911-4

来源: Springer

【 摘 要 】

BackgroundOverweight and obesity are common features of the rare disease Bardet–Biedl syndrome (BBS). Sleep and physical activity are behaviors that might impact overweight and obesity and thus may play a key role in the health and well-being of people with BBS. Objectively-measured sleep and physical activity patterns in people with BBS are not well known. We evaluated objectively-measured sleep and physical activity patterns in the largest cohort to date of people with BBS.ResultsShort sleep duration, assessed using wrist-worn accelerometers, was common in both children and adults with BBS. Only 7 (10%) of adults and 6 (8%) of children met age-specific sleep duration recommendations. Most adults 64 (90%) achieved recommended sleep efficiency. The majority of children 26 (67%) age 6–12 years achieved recommended sleep efficiency, but among children age 13–18, only 18 (47%). In both adults and children, sleep duration was significantly negatively correlated with duration of prolonged sedentary time. In children age 6–12 sleep duration was also significantly related to total activity score, children with lower sleep duration had lower total activity scores.ConclusionsInsufficient sleep duration is very common in people with BBS. Prolonged sedentary time and short sleep duration are both potentially important health-related behaviors to target for intervention in people with BBS.

【 授权许可】

CC BY