The three syndromes and six Chinese patent medicine study during the recovery phase of COVID-19

Chinese Medicine

Fengmei Lian¹  Xiaolin Tong¹  Rong Rong Zhou²  Yingying Duan²  Shenghui Zhao²  Liyun Duan³  Yue Hong Zhang³  De Jin³  Xuedong An³ 

[1] Department of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, 100053, Beijing, China;Department of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, 100053, Beijing, China;Beijing University of Chinese Medicine, 100029, Beijing, China;Department of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, 100053, Beijing, China;China Academy of Chinese Medical Sciences, 100700, Beijing, China;

关键词: COVID-19;    Recovery period;    COVID-19 sequelae;    Three syndromes and six Chinese patent medicines;   

DOI  :  10.1186/s13020-021-00454-x

来源: Springer

【 摘 要 】

The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), first broke out in Wuhan, China, in 2019. SARS-CoV-2 develops many types of mutations (such as B.1.1.7), making diagnosis and treatment challenging. Although we now have a preliminary understanding of COVID-19, including pathological changes, clinical manifestations, and treatment measures, we also face new difficulties. The biggest problem is that most COVID-19 patients might face sequelae (e.g., fatigue, sleep disturbance, pulmonary fibrosis) during the recovery phase. We aimed to test six Chinese patent medicines to treat three major abnormal symptoms in COVID-19 patients during the recovery phase, including cardiopulmonary function, sleep disturbance, and digestive function. We launched the “three syndromes and six Chinese patent medicines” randomized, double-blind, placebo-controlled, multicenter clinical trial on April 10, 2020. The results showed that Jinshuibao tablets and Shengmaiyin oral liquid significantly improved the cardiopulmonary function of recovering COVID-19 patients. Shumian capsules, but not Xiaoyao capsules, significantly improved patients’ sleep disorders. This might be because the indication of Xiaoyao capsules is liver qi stagnation rather than psychological or emotional problems. Xiangsha Liujun pills and Ludangshen oral liquid significantly improved digestive function. Our research provides a guideline for treating COVID-19 sequelae in patients during the recovery period based on high-quality evidence.

【 授权许可】

CC BY