An immune-related model based on INHBA, JAG2 and CCL19 to predict the prognoses of colon cancer patients

Cancer Cell International

Jia Yan¹  Yaxu Wang²  Yahui Jiang²  Xuankun Yang³ 

[1] Department of Gastroenterology, University-Town Hospital of Chongqing Medical University, Chongqing, China;Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, No. 288 Tianwen Road, Nanan District, 401336, Chongqing, China;Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, No. 288 Tianwen Road, Nanan District, 401336, Chongqing, China;Department of General Surgery, Hechuan District People’s Hospital, Chongqing, China;

关键词: CCa;    Immune-related genes;    Immune-related risk score;    Prognosis;   

DOI  :  10.1186/s12935-021-02000-z

来源: Springer

【 摘 要 】

BackgroundColorectal cancer (CRC) is the leading cause of cancer deaths and most common malignant tumors worldwide. Immune-related genes (IRGs) can predict prognoses of patients and the effects of immunotherapy. A series of colon cancer (CCa) samples from The Cancer Genome Atlas (TCGA) were analyzed to provide a new perspective into this field.MethodsDifferential IRGs and IRGs with significant clinical outcomes (sIRGs) were calculated by the limma algorithm and univariate COX regression analysis. The potential molecular mechanisms of IRGs were detected by PPI, KEGG and GO analysis. Immune-related risk score model (IRRSM) was established based on multivariate COX regression analysis. Based on the median risk score of IRRSM, the high-risk group and low-risk group were distinguished. The expression levels of IHNBA and JAG2 and relationships between IHNBA and clinical features were verified by RT-qPCR.Results6 differential sIRGs of patients with CCa were selected by univariate COX regression analysis. Based on the sIRGs (INHBA, JAG2 and CCL19), the IRRSM was established to predict survival probability of CCa patients and to explore the potential correlations with clinical features. Furthermore, IRRSM reflected the infiltration status of 22 types of immune cells. The expression levels of IHNBA and JAG2 were higher in CCa tissues than that in adjacent normal tissues. The expression levels of IHNBA and JAG2 were increased in advanced T stages.ConclusionOur results illustrated that some sIRGs showed the latent value of predicting the prognoses of CCa patients and the clinical features. This study could provide a new insight for immune research and treatment strategies in CCa patients.

【 授权许可】

CC BY