Prevalence and molecular characteristics of drug-resistant Mycobacterium tuberculosis in Hainan, China: from 2014 to 2019

BMC Microbiology

Hua Pei¹  Zheng Bei²  Sijing Li³  Lin Liu³  Xingyong Wu³  Biao Liu³  Mamy Jayne Nelly Rajaofera³  Yingfei Zeng³  Sufang Dong³  Qianfeng Xia³  Xiujuan Zhao⁴ 

[1] Department of Clinical Laboratory, The Second Affiliated Hospital, Hainan Medical University, 570311, Haikou, China;Hainan Province cadre sanatorium, Hainan Province Geriatric Hospital, 571100, Haikou, China;NHC Key Laboratory of Control of Tropical diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Tropical Medicine and Laboratory Medicine, Hainan Medical University, 571199, Haikou, China;Public Health School, Hainan Medical University, 571199, Haikou, Hainan, China;

关键词: Mycobacterium tuberculosis;    DNA microarray;    Drug sensitivity test;    Molecular-characteristics;    Drug-resistant rate;   

DOI  :  10.1186/s12866-021-02246-7

来源: Springer

【 摘 要 】

BackgroundThe emergence of antimicrobial resistance against Mycobacterium tuberculosis (M. tuberculosis) has become the major concern in global tuberculosis control due to its limited therapy options and high mortality. However, the clinical and molecular characteristics of drug-resistant strains vary in different geographical areas. Hainan Island located in southern China, is a high drug-resistant tuberculosis burden area. This study aimed to determine the dynamic changes of drug-resistance patterns and drug-related gene mutation types of M. tuberculosis in Hainan from 2014 to 2019.ResultsA total of 1484 culture-confirmed M. tuberculosis were included in this study. It was found that the proportions of drug resistance to isoniazid and rifampin were 31.3 and 31.1% respectively. Overall the proportion of multidrug resistant M. tuberculosis was 24.9%. Multivariate logistic regression analysis showed that age and the treatment history were independent influencing factors of drug resistant tuberculosis. The proportions of drug-resistant tuberculosis in retreatment patients were considerably higher than those in new patients. The most common mutation types of isoniazid were Ser315 → Thr (66.3%), and the most common mutation types of rifampin were Ser531 → Leu (41.5%).ConclusionsOur data suggests that the prevalence of drug resistant TB remains high in Hainan, and the risks for developing drug resistance with diversified mutation types increased significantly in retreatment patients. These results contribute to the knowledge of the prevalence of drug resistance in Hainan Province and expand the molecular characteristics of drug resistance in China simultaneously.

【 授权许可】

CC BY