The promising shadow of microbubble over medical sciences: from fighting wide scope of prevalence disease to cancer eradication

Journal of Biomedical Science

Amir Hossein Meisami¹  Ali Jangjou²  Milad Abbasi³  Mostafa Shafiee³  Ali Mohammad Amani³  Ahmad Vaez⁴  Majid Salehi⁵  Ahmad Hosseinzadeh⁶  Mohammad Hadi Niakan⁷  Kazem Jamali⁷ 

[1] Department of Emergency Medicine, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran;Department of Emergency Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran;Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran;Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran;Tissue Engineering and Stem Cells Research Center, Shahroud University of Medical Sciences, Shahroud, Iran;Thoracic and Vascular Surgery Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran;Trauma Research Center, Shahid Rajaee (Emtiaz) Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Iran;

关键词: Microbubbles;    Biomedicine;    Drug delivery;    Cancer treatment;    Nanoparticles;   

DOI  :  10.1186/s12929-021-00744-4

来源: Springer

【 摘 要 】

Microbubbles are typically 0.5–10 μm in size. Their size tends to make it easier for medication delivery mechanisms to navigate the body by allowing them to be swallowed more easily. The gas included in the microbubble is surrounded by a membrane that may consist of biocompatible biopolymers, polymers, surfactants, proteins, lipids, or a combination thereof. One of the most effective implementation techniques for tiny bubbles is to apply them as a drug carrier that has the potential to activate ultrasound (US); this allows the drug to be released by US. Microbubbles are often designed to preserve and secure medicines or substances before they have reached a certain area of concern and, finally, US is used to disintegrate microbubbles, triggering site-specific leakage/release of biologically active drugs. They have excellent therapeutic potential in a wide range of common diseases. In this article, we discussed microbubbles and their advantageous medicinal uses in the treatment of certain prevalent disorders, including Parkinson's disease, Alzheimer's disease, cardiovascular disease, diabetic condition, renal defects, and finally, their use in the treatment of various forms of cancer as well as their incorporation with nanoparticles. Using microbubble technology as a novel carrier, the ability to prevent and eradicate prevalent diseases has strengthened the promise of effective care to improve patient well-being and life expectancy.

【 授权许可】

CC BY