Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder

Molecular Autism

Richard E. Frye¹  Indrapal N. Singh¹  Li-Ching Lee²  Stepan Melnyk³  S. Jill James³  Hua Liu⁴  Jed W. Fahey⁵  Anita A. Panjwani⁶  Eileen Diggins⁷  Andrew W. Zimmerman⁷  Susan L. Connors⁷  Kanwaljit Singh⁷  Ann Foley⁷ 

[1] Barrow Neurologic Institute at Phoenix Children’s Hospital and Department of Child Health, University of Arizona College of Medicine – Phoenix, 475 N. 5th St., 85004, Phoenix, AZ, USA;Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., 21205, Baltimore, MD, USA;Department of Pediatrics, University of Arkansas for Medical Sciences, 4301 W. Markham St., 72205, Little Rock, AR, USA;Department of Pharmacology and Molecular Sciences, and The Cullman Chemoprotection Center, Johns Hopkins University School of Medicine, 725 N. Wolfe St., 21205, Baltimore, MD, USA;Department of Pharmacology and Molecular Sciences, and The Cullman Chemoprotection Center, Johns Hopkins University School of Medicine, 725 N. Wolfe St., 21205, Baltimore, MD, USA;Department of Psychiatry and Behavioral Sciences, and iMIND Hopkins, Johns Hopkins University School of Medicine, 600 N. Wolfe St., 21287, Baltimore, MD, USA;Department of Medicine, Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, 600 N. Wolfe St., 21287, Baltimore, MD, USA;Department of Psychiatry and Behavioral Sciences, and iMIND Hopkins, Johns Hopkins University School of Medicine, 600 N. Wolfe St., 21287, Baltimore, MD, USA;Department of Psychological Sciences, Purdue University, 703 3rd St., 47907, West Lafayette, IN, USA;Departments of Pediatrics, Neurology and Psychiatry, University of Massachusetts Medical School, 55 N. Lake Ave., 01655, Worcester, MA, USA;

关键词: Sulforaphane;    Clinical trial;    Autism spectrum disorder (ASD);    Biomarkers;    Placebo effects;   

DOI  :  10.1186/s13229-021-00447-5

来源: Springer

【 授权许可】

CC BY