Role of Lactobacillus in Female Infertility Via Modulating Sperm Agglutination and Immobilization

Frontiers in Cellular and Infection Microbiology

Tingtao Chen¹  Fenghao Zhang¹  Jie Dai² 

[1] Institute of Translational Medicine & School of Life Sciences, Nanchang University, Nanchang, China;Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital and Institute, Beijing, China;

关键词: vaginal microbiota;    bacterial adherence;    Lactobacillus;    unexplained infertility;    sperm agglutination;   

DOI  :  10.3389/fcimb.2020.620529

来源: Frontiers

【 摘 要 】

Infertility has become a common problem in recent decades. The pathogenesis of infertility is variable, but microbiological factors account for a large proportion of it. Dysbiosis of vaginal microbiota is reportedly associated with female infertility, but the influence of normal vaginal microbiota on infertility is unclear. In this review, we summarize the physiological characteristics of the vaginal tract and vaginal microbiota communities. We mainly focus on the bacterial adherence of vaginal Lactobacillus species. Given that the adherent effect plays a crucial role in the colonization of bacteria, we hypothesize that the adherent effect of vaginal Lactobacillus may also influence the fertility of the host. We also analyze the agglutination and immobilization effects of other bacteria, especially Escherichia coli, on ejaculated spermatozoa, and speculate on the possible effects of normal vaginal microbiota on female fertility.

【 授权许可】

CC BY